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OTUD4 deubiquitinates SETDB1. 3 / 3
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"The ubiquitination experiments showed OTUD4 knockout increased SETDB1 ubiquitination ( Fig. S5A ), leading to its degradation ( Fig. 4 F)."
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"Conversely, the wild type (WT) OTUD4, but not OTUD4 C45A , reduced SETDB1 ubiquitination in liver cancer cells ( Fig. S5B ), even this OTUD4 C45A variant could still bind to IRTKS ( Fig. S5C ), which [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These data indicate that OTUD4 can deubiquitinate SETDB1 in the presence of IRTKS, enhancing its stability.Ubiquitin conjugates with proteins via several residues including K48, which directs polyubiq[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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