IndraLab

Statements

PKA inhibits KCNMA1. 7 / 7
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"Palmitoylation at Cys12 and 13 within the stress-regulated exon insert plays a regulatory role in protein kinase A-mediated inhibition of the BK channel but has no effect on trafficking to the cell su[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23388354
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"Importantly, knockdown of these DHHCs also controlled PKA-dependent inhibition of the STREX BK channel that we have previously shown to be the major functional effect of palmitoylation of STREX in BK channels ( xref )."
20507996
sparser
"Interpretation of these results in light of the effects of these inhibitors on the flow-induced elevation of [Ca2+](i) suggests that the principal cell apical BK channel is tonically inhibited by PKA and that flow stimulation of J(K) in the CCD is PKA and PKC dependent."
19656909
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"However, PKA mediated inhibition of BK channel activity in isolated patches from steroid treated cells was severely blunted."
9593688
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"Interestingly in non pregnant myometrium, PKA can also cause inhibition of the MaxiK channel [XREF_BIBR] but the triggering membrane receptor and mechanism of this response is unknown."
24077696
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"Patch clamp recordings from adult and juvenile bag cell neurons confirmed that PKA decreases BK channel activity only in adults."
15375169
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"Importantly, knockdown of these DHHCs also controlled PKA dependent inhibition of the STREX BK channel that we have previously shown to be the major functional effect of palmitoylation of STREX in BK channels."
20507996