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TNF activates KCNK2. 2 / 2

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"We recently reported the expression of K2P channels in alveolar epithelial cells (AECs) and found that TNF-alpha stimulation of TREK-1 deficient AECs caused decreased IL-6 secretion but increased MCP-1 secretion in vitro [XREF_BIBR, XREF_BIBR]."

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"Although activation of several TNF-alpha induced signaling pathways, including p38 kinase and the PKCtheta isoform, appeared altered in TREK-1 deficient epithelial cells, the specific regulatory mechanisms underlying these signaling changes remains unclear."

25126877

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TNF activates KCNK2. 2 / 2

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