IndraLab

Statements

USP22 activates PTGS2. 3 / 4
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"Our results showed that USP22 silencing downregulated COX-2 and FBP1 in A549 and NCI-H460 cells compared to control siRNA."
25817787
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"Here, we identified COX-2 as a substrate of USP22 and investigated the role of USP22 in tumorigenesis via the modulation of COX-2 stability and activity.In the present study, we showed that silencing [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25817787
reach
"Silencing of USP22 downregulated COX-2, decreased its half-life, and inhibited lung carcinoma cell proliferation by directly interacting with and modulating the stability and activity of COX-2 through the regulation of its ubiquitination status."
25817787