IndraLab

Statements

TNF binds NRP1. 5 / 7
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"To further understand the mechanism by which the NRP1-TNF-α receptor axis promotes renal injury, we analyzed transcription factor activities in Nrp1  + DT and Nrp1 -DT."
38977708
sparser
"Furthermore, to validate the binding of TNFα to cell surface NRP1 which is in an oligomeric state ( xref ; xref ; xref ; xref ; xref ), HEK293 cells were transfected with plasmids to overexpress TNFR1, TNFR2 and NRP1, respectively, and then co-cultured with GpL-TNFα."
38994453
sparser
"Secondly, we demonstrated that Nrp1 interacts with the TNF-α receptor Tnr1a, influencing downstream signaling pathways, ultimately leading to decreased Kcr of Cox4i1 in renal tubular epithelial cells."
38977708
sparser
"The expression of TNF-α is known to increase during renal injury xref , and our research revealed that TNF-α interacts with Nrp1 and Tnr1a, leading to downstream events that inhibit the crotonylation of the aerobic metabolism-related enzyme Cox4i1 through Nfkb1 activation."
38977708
reach
"Although a binding interface between NRP1 and TNFα/TNFRs was predicated in the protein docking model, the binding assays in cell-free microplates and cultured cells did not support the direct binding of NRP1 to TNFα/TNFRs (Figure 4)."
38994453