IndraLab

Statements

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"In functional studies, depletion of BAP1 protein in the 92.1 UM cell line using siRNAs led to a change in cell morphology from spindle to a more epithelioid phenotype, loss of melanocytic differentiation and transition from a ' class 1 ' to a ' class 2 ' gene expression profile."
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"BAP1 loss also leads to the failure of the H3K27ac histone mark to accumulate at the promoter sites of key lineage commitment genes, highlighting its role in the broader regulation of transcription and cell differentiation (19)."
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"The recent finding that BAP1 loss leads to defective differentiation and an arrested primitive phenotype in vertebrate development and uveal melanoma suggests that BAP1 loss can promote tumor progression by inducing cell dedifferentiation and stem like behavior."
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"Studies suggest that down regulated expression of BAP1 led to impaired differentiation in UM cells."
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"Consistent with those results, treatment of BAP1 deficient uveal melanoma cells with an HDAC inhibitor restored the expression of the melanocyte differentiation markers, which were down-regulated by BAP1 depletion, in a dose dependent manner."
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"Depletion of BAP1 in cultured class 1 UM cells induced a loss of melanocytic differentiation and acquisition of a class 2 gene expression profile, suggesting that the loss of BAP1 may be mechanistically linked to metastasis."
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"Instead, prenatal Bap1 loss profoundly impairs postnatal enteric neuron differentiation and induces postnatal enteric neuron loss."
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"ASXL1-MT and BAP1 impairs multilineage differentiation of HSPCs."
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"However, as previously reported, depletion of BAP1 in UM cells induced loss of melanocytic differentiation together with acquisition of a gene expression profile seen in advanced metastasizing tumors."
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"ASXL1-MT alone modestly, and coexpression of ASXL1-MT and BAP1 dramatically blocked G-CSF-induced granulocytic differentiation of 32Dcl3."
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"BAP1 loss induces stem-like features and loss of differentiation in UM cells, promoting a more aggressive phenotype."
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"In mice, BAP1 loss in the germ line is embryonic lethal (10), and BAP1 loss in the developing kidney causes differentiation failure and tumorigenesis (11)."
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"Based on these data, we propose that BAP1 O -GlcNAcylation promotes RAR repression required for maintaining pluripotency, while its inhibition allows RAR activation to initiate ES cell differentiation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Such as, the mutant ASXL1 (ASXL1-MT)/BAP1 complex can impair the multidirectional differentiation of HSPCs (except to monocytes) and promote RUNX1-ETO-induced murine c-Kit+ progenitor cell leukemogenesis by removing H2AK119ub, which drives the upregulation of the HOXA gene and interferon regulatory factor 8 (IRF8) [135]."
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"Defects in BAP1 disrupt DNA replication, DNA repair, calcium homeostasis, cell proliferation and differentiation, and cell metabolism [34]."
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