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Statements

USP8 is phosphorylated on S718. 21 / 21
7 | 12 2
sparser
"In addition, EMCV induced the phosphorylation of USP8 at S718 in a time‐dependent manner, which was tightly correlated with the induction of MDA5 protein expression (Figure  xref )."
40525588
rlimsp
"The phosphorylation of USP8 on the fourth serine (S718) of its 14-3-3 binding motif results in its binding with 14-3-3 proteins and catalytic inactivation."
25675982
sparser
"It is found that viral infection modulates the AKT‐dependent phosphorylation of USP8 at serine 718, which not only promotes the activation of USP8 but also enhances the association between USP8 and MDA5 and the consequent deubiquitination and stabilization of MDA5."
40525588
sparser
"For example, the Ser680 residue of USP8 is phosphorylated during the interphase stage of cell division, which enables USP8 to bind to the 14-3-3 protein."
36142702
hprd
No evidence text available
20068231
hprd
No evidence text available
20166139
hprd
No evidence text available
20230923
sparser
"USP8 phosphorylation at residue S680 was also identified in a phosphoproteomic analysis [52] and this phosphorylation site was shown to be essential for a USP8/14-3-3ɛ complex formation and for USP8 l[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17961905
hprd
No evidence text available
18452278
hprd
No evidence text available
19664994
hprd
No evidence text available
19651622
hprd
No evidence text available
18669648
rlimsp
"Metabolic labeling with [(32)P]orthophosphate and immunoblotting using antibody against the phosphorylated 14-3-3-binding motif showed that Ser(680) is a major phosphorylation site in UBPY."
17720156
sparser
"This phosphorylation of USP8 at S680 permits complex formation with 14-3-3 proteins ."
28923280
sparser
"We therefore examined whether UBPY undergoes phosphorylation at Ser 680 ."
17720156
sparser
"These results suggest that AKT activates USP8 by directly phosphorylating USP8 at serine 718."
40525588
sparser
"As with Usp8 phosphorylation of S680, serine phosphorylation of USP16 and USP44 plays a role during mitosis [35,63,64] ."
23333852
sparser
"The study found that phosphorylation of USP8 at serine 680 was essential for its interaction with 14-3-3epsilon and for retaining/stabilizing USP8 in the cytosol [ xref ]."
18687060
sparser
"In the interphase stage of cell division, the Ser680 residue of USP8 is phosphorylated, which enables USP8 to bind to the 14-3-3 protein This binding in turn inhibits the catalytic activity of USP8 ( xref ) ( xref )."
34177595
sparser
"The first is a stabilized autoinhibited state with the lowest activity in which USP8 is phosphorylated at S718 and bound by 14-3-3."
39214302
sparser
"Phosphorylation of the deubiquitinating enzyme USP8 at serine 680 was found essential for its interaction with 14-3-3epsilon and for maintaining USP8 in the cytosol."
16944949