IndraLab

Statements

Resveratrol inhibits NFKBIA. 8 / 8
1 | 4 3
reach
"In the normal skin keratinocytes, resveratrol doses (5, 10, and 25muM) blocked UVB mediated (40mJ/cm 2) activation of NF-kappaB, phosphorylation and degradation of IkappaBalpha, and activation of IKKalpha [XREF_BIBR]."
24757666
reach
"Interestingly, Resveratrol, which blocks MyD88 independent, Toll and IL-1R domain containing adaptor inducing IFN-beta signaling in the TLR4 pathway [XREF_BIBR], inhibited I k Balpha degradation at the early time point, but not at a later time point (30 minutes) after LPS treatment."
19544467
eidos
"Moreover , resveratrol could suppress p300 expression and promote IkappaBalpha degradation , while it remains unclear whether this process occurs through the activation of Sirt1 [ 104 ] ."
| PMC
eidos
"Several studies in the N9 microglial cell line have indicated that resveratrol attenuates LPS-induced phosphorylation of p38 MAPK and degradation of IkappaB-alpha , thus reducing the production of NO and TNF-alpha [ 64,67 ] ."
21350391
eidos
"Resveratrol dose-dependently inhibits IKKalpha , IkappaBalpha , and NF-kappaB activation in vitro ( Capiralla et al ., 2012 , Zhao et al ., 2018 ) and suppress NF-kappaB in vivo ( Capiralla et al ., 2012 , Poulose et al ., 2015 ) ."
33872681
eidos
"In contrast , resveratrol did not inhibit the degradation of IkappaBalpha nor the phosphorylation and nuclear translocation of p65 NF-kappaB in TNFalpha treatments ."
32645860
reach
"Resveratrol reversed these effects, increasing cytosolic IkappaBalpha and decreasing nuclear p65."
33513742
ctd
No evidence text available
22363816