IndraLab

Statements

Celecoxib inhibits KCNH2. 6 / 6
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"Inhibition of hERG Potassium Channels by Celecoxib and Its Mechanism."
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"Inhibition of HERG potassium channels by celecoxib and its mechanism."
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"In an ex-vivo experiment, celecoxib inhibited hERG channels [12]."
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"Indeed, celecoxib significantly decreased the tau act of hERG below +30 mV, tau inact below +40 mV, and tau rec between -60 and -20 mV where the electrical driving forces for the respective transitions were relatively small."
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"Extra cellular application of celecoxib causes rapid suppression of hERG channels which induces the cardiac disturbances [XREF_BIBR]."
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"Celecoxib inhibited the hERG, SCN5A, KCNQ1 and KCNQ1 and MinK channels expressed in HEK-293 cells with IC 50 s of 6.0 microM, 7.5 microM, 3.5 microM and 3.7 microM respectively, and the KCND3 and KChiP2 channels expressed in CHO cells with an IC 50 of 10.6 microM."
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