IndraLab

Statements

Tamoxifen activates USP1. 4 / 4
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"Peptide-N-glycosidase treatment of USP-1 induced by E2 or tamoxifen removed asparagine linked carbohydrate chains and resulted in the appearance of polypeptides with apparent mol wt of 91K and 105K, respectively."
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"Thus, the higher mol wt of tamoxifen induced USP-1 is not due to changes in asparagine linked carbohydrates."
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"Sodium dodecylsulfate-polyacrylamide gel analysis of immunoprecipitable [35S] methionine labeled protein revealed that USP-1 induced by tamoxifen is larger (110K) than that induced by estrogen or LY117018 (97K)."
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"By radioimmune precipitation assay of [35S] methionine labeled uterine luminal fluid proteins, it was shown that tamoxifen and LY117018 could weakly induce USP-1 compared with E2."
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