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USP15 deubiquitinates SMURF2 on K734. 2 / 2
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"USP15 deubiquitinates Smurf2 at Lys734, a residue required for Smurf2 transthiolation and catalytic activity."

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"These authors performed proteomic analysis and found that USP15 deubiquitinates Smurf2 on Lys734, a residue required for Smurf2 catalytic activity, leading to enhanced TGF-beta signalling (Iyengar et [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"