IndraLab

Statements

CYLD activates TNF. 15 / 19
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"Overexpressing CYLD led to significant decreases in LPS-induced TNF-α and IL-6, at both the transcription and translation levels, compared to an empty vector (EV) (Fig. 3C, D)."
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"Similarly, knockdown CYLD in EMT6 cells and in murine BMDMs inhibited TNF/IFNγ-induced death (Fig. S4, A–D)."
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"RNAi mediated silencing of CYLD attenuates ROS production and TNF induced programmed necrosis [XREF_BIBR]."
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"Consistent with a role in programmed necrosis, CYLD promotes the assembly of the RIP1-FADD-caspase 8 complex in response to TNF, IAP antagonist, and zVAD-fmk treatment [XREF_BIBR]."
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"Overexpression of CYLD via lentivirus reduced the infarct area, decreased inflammatory markers (IL-1β and TNF-α), and improved behavioral outcomes after 72 h."
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"CYLD knockdown also significantly inhibited TNF/IFNγ-induced cell death (Fig. 3, E and F), and combined knockdown of caspase-8 and CYLD inhibited TNF/IFNγ-induced cell death in an additive manner (Fig. 3, G and H)."
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"CYLD Limits Gene Activation and Enhances Cell Death in Response to TNF."
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"Moreover, overexpression of CYLD increased TNF-alpha induced cell apoptosis in A549 cells."
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"Hence, the deubiquitinase function of CYLD is required to promote TNF induced programmed necrosis."
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"Collectively, our results indicated that IFNγ-stimulated caspase-8 and CYLD upregulation additively promoted TNF/IFNγ-induced cell death in cancer cells."
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"From the above set of results, we learned that IFNγ-induced CYLD and caspase-8 upregulation additively underlie the mechanism of IFNγ’s synergism to promote TNF-initiated cell death."
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"In addition, CD11c-Cre Cyld (ex7/8 fl/fl) DCs produced more TNF, IL-10, and IL-12 upon infection, which led to enhanced stimulation of IFN-gamma-producing NK cells."
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"Consistent with the observation that upregulation of the complex I deubiquitinase CYLD promotes TNF-initiated cell death, decreasing the activity of E3 ligase LUBAC complex sensitizes cells to TNF/IFNγ-induced cell death (Freeman et al., 2021)."
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"CYLD deficient cells are protected from RIPK1 mediated necroptosis in response to TNF plus caspase inhibition with or without Smac mimetic."
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"Further, whether IFNγ-upregulated CASP8 and CYLD promote TNF-initiated cell death is not genetically validated."
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