IndraLab

Statements

USP28 is sumoylated on K99. 5 / 5
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"The present study found that the deubiquitinase USP28 was SUMOylated at K99 under normoxic condition but rapidly deSUMOylated by SENP1 during hypoxia."
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"SUMOylation of USP28 at K99 or direct fusion of SUMO2 to USP28 inhibits its DUB activity [128] ."
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"Therein, the USP28-inactivating sumoylation of USP28 at K99 occurring under normoxia is reversed by direct interaction with SENP1 [ xref ]."
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"A study showed that SUMOylation at Lys99 residues of USP28 could inhibit the activity of USP28 ( xref ), indicating potential therapeutic role in colon cancer cells and NSCLC cells ( xref ; xref ; xref )."
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"The K99R mutant USP28 showed much stronger efficiency against HIF-1α ubiquitination in vivo compared with USP28 WT (Fig.  xref ), suggesting that SUMOylation of USP28 at K99 inhibits its deubiquitinating activity on HIF-1α."
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