IndraLab

Statements

CYLD inhibits TNFRSF11A. 8 / 8
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reach
"Further, the de-ubiquitinase CYLD has been shown to inactivate TRAF6 downstream of RANK in osteoclasts, as evidenced by removal of polyubiquitin chains, and the physiologic relevance of this mechanism is supported by the phenotype of CYLD deficient osteoclasts, which exhibit hyper-responsiveness to RANK."
26085208
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"Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice."
18382763
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"Thus, CYLD inhibits RANK mediated signaling function by deubiquitinating TRAF6 or its downstream targets involved in NF-kappaB activation."
19373246
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"CYLD inhibits RANK mediated signaling in osteoclasts in a negative feedback loop by deubiquitinating TRAF6 (XREF_FIG)."
22435550
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"The deubiquitinating enzyme, CYLD has been shown to interact with p62 UBA domain to inhibit TRAF6 ubiquitination and thereby negatively regulates RANK signaling and osteoclastogenesis."
22105856
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"Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [XREF_BIBR]."
21639951
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"Deubiquitinating enzyme cylindromatosis (CYLD) has been shown to negatively regulate RANK ligand-RANK signaling essential for OCL differentiation."
21878516
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"In addition, CYLD negatively regulates RANK signaling, which is known to be a key factor in bone resorption in cholesteatoma [XREF_BIBR]."
20414373