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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MBNL1 activates ATXN3. 2 / 2

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"In experiments on polyQ-expanded ataxin-3 induced neurodegeneration in Drosophila, the authors found that the RNA binding protein MBNL1, a known player in neurodegeneration discussed below, enhances toxicity of a CAG-expanded SCA3 transgene."

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"Rather, our findings in FUS-linked ALS are consistent with previous work performed in a Drosophila model for spinocerebellar ataxia type 3, in which overexpression of MBNL1-enhanced ataxin-3 induced neurodegeneration ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...