IndraLab

Statements

MBNL1 activates ATXN3. 2 / 2
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"In experiments on polyQ-expanded ataxin-3 induced neurodegeneration in Drosophila, the authors found that the RNA binding protein MBNL1, a known player in neurodegeneration discussed below, enhances toxicity of a CAG-expanded SCA3 transgene."
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reach
"Rather, our findings in FUS-linked ALS are consistent with previous work performed in a Drosophila model for spinocerebellar ataxia type 3, in which overexpression of MBNL1-enhanced ataxin-3 induced neurodegeneration ."
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