IndraLab

Statements

Modified UCHL1 increases the amount of Ubiquitin. 4 / 4
| 4
reach
"Our studies are consistent with previously published results that demonstrate that loss of Uch-L1 causes a decrease in ubiquitin levels in neurons."
18771733
reach
"Overexpression of UCHL1 significantly elevated free ubiquitin levels (p < 0.05) (XREF_FIG), and overexpression of ubiquitin further increased free ubiquitin levels (p < 0.01) (XREF_FIG)."
25466238
reach
"Ubiquitin C-terminal hydrolase L1 (UCHL1) plays an important role in maintenance of nervous system integrity, and overexpression of UCHL1 has been shown to increase ubiquitin levels within neurons."
31932518
reach
"Furthermore, they also found that overexpression of wild type UCH-L1, which significantly up-regulated free monomeric ubiquitin levels, did not alter proteasome activity in vitro."
19535597