IndraLab

Statements


Modified UCHL1 increases the amount of Ubiquitin. 4 / 4
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"Our studies are consistent with previously published results that demonstrate that loss of Uch-L1 causes a decrease in ubiquitin levels in neurons."

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"Overexpression of UCHL1 significantly elevated free ubiquitin levels (p < 0.05) (XREF_FIG), and overexpression of ubiquitin further increased free ubiquitin levels (p < 0.01) (XREF_FIG)."

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"Ubiquitin C-terminal hydrolase L1 (UCHL1) plays an important role in maintenance of nervous system integrity, and overexpression of UCHL1 has been shown to increase ubiquitin levels within neurons."

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"Furthermore, they also found that overexpression of wild type UCH-L1, which significantly up-regulated free monomeric ubiquitin levels, did not alter proteasome activity in vitro."