IndraLab

Statements

UCHL3 leads to the ubiquitination of TDP1. 3 / 3
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"Depletion of UCHL3 increases TDP1 ubiquitylation and turnover rate and sensitizes cells to TOP1 poisons."
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"In contrast, UCHL3 is downregulated in spinocerebellar ataxia with axonal neuropathy (SCAN1), causing elevated levels of TDP1 ubiquitylation and faster turnover rate."
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"To examine if the increased TDP1 ubiquitylation caused by UCHL3 depletion would lead to increased turnover, we monitored the TDP1 protein level following incubations with the protein synthesis inhibitor cycloheximide."
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