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KCNA3 inhibits SHPK. 3 / 3
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"As shown in Fig. 2 C, the cells infected with lentivirus of a known Kv1.3 blocking venom peptide ShK [ 18 ] exhibited 29.2% tdTomato positive cells, while the cells infected with an irrelevant virus o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"An early phase study of Kv1.3 channel-blocking ShK analog (ShK-186/dalazatide) in humans has demonstrated safety, supported by multiple pre-clinical studies showing safety and efficacy of Kv1.3 blockers in models of systemic autoimmunity, obesity, CNS demyelinating disorders, and neurodegeneration [15, 18, 28, 42–44], suggesting that rapid translation of Kv1.3 blockers to ischemic stroke is feasible [45]."
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"siRNA knockdown of KCNA3 reversed the inhibitory effects of ShK, rendering GAD65 specific T-cell proliferation and IFN-gamma responses unaffected by ShK (XREF_FIG)."
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