IndraLab

Statements

OTUB1 deubiquitinates YAP1. 3 / 3
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"Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) mediates YAP phosphorylation and affects cellular energy pressure metabolism [32], while mammalian target of rapamycin complex-2 (mTORC2) directly phosphorylates YAP (Ser 463), enhancing YAP activity and promoting the malignant phenotype of glioblastoma [33]; the deubiquitinase OTUB1 reduces YAP ubiquitination levels and inhibits YAP degradation, thereby promoting the proliferation activity of gastric cancer cells [34]."
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"For instance, USP9X, ubiquitin-specific peptidase 47 (USP47), and OTU deubiquitinase ubiquitin aldehyde binding 1 (OTUB1) directly deubiquitinate YAP [33–35]."
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"They found OTUB1 decreases YAP1 ubiquitination and promotes YAP1 protein stability."
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