IndraLab

Statements

KCNH2 binds beta1 integrin. 15 / 15
| 15
reach
"These data pave the way for a novel therapeutic approach to PDAC, based on the combination of low doses of a chemotherapeutic drug (to minimize adverse side effects and the onset of resistance) and the novel scDb-hERG1-beta1 targeting the hERG1/beta1 integrin complex as neoantigen."
37046674
reach
"In a subset of samples, a different antibody directed against the hERG1/beta1 integrin complex was also used."
36142530
reach
"This antibody has been proven to target with high affinity the hERG1/beta1 integrin complex and to exert a good antineoplastic activity in preclinical mouse models."
37767396
reach
"Overall, hERG1 may stimulate nuclear translocation of p65, thus regulating the NF-kappaB pathway through the activation of the hERG1 and beta1 integrin complex and PI3K and AKT signaling."
27076857
reach
"The dynamics of hERG1/beta1 integrin complex formation."
37923359
reach
"The hERG1/beta1 integrin complex regulates hERG1 localization to the plasma membrane."
37923359
reach
"A biochemical network model of the dynamics of hERG1 and beta1 integrin interaction."
37923359
reach
"Interestingly, hERG1, nNav1.5 and the hERG1/beta1 integrin complex associated with several clinical features, including molecular subtype and hormone receptor status."
39865220
reach
"Conclusion: hERG1/beta1 integrin interaction in cancer cell migration."
37923359
reach
"Our preliminary results suggest that the HERG channel proteins form a complex with the beta1 integrin, in a manner similar to that in SH-SY5Y neuroblastoma cells and HEK-293 cells stably transfected w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19765650
reach
"Both effects are mediated by the formation of a hERG1 and beta1 integrin complex."
20549940
reach
"Harnessing the hERG1 and beta1 integrin complex via a novel bispecific single-chain antibody : an effective strategy against solid cancers."
34045227
reach
"Here, we describe a new therapeutic strategy based on a single chain bispecific antibody (scDb-hERG1-beta1) which targets a cancer-specific antigen, i.e., the complex formed by the K + channel hERG1 and the beta1 integrin (hERG1/beta1 integrin complex)."
37046674
reach
"With the aim of improving the treatment outcome of PDAC, we tested the effect of combining Gemcitabine with a novel single chain bispecific antibody (scDb) targeting the cancer-specific hERG1/beta1 integrin complex."
37046674
reach
"First, using the scDb (scDb-hERG1-beta1) in immunohistochemistry (IHC), Western blot (WB) analysis and immunofluorescence (IF), we confirmed the presence of the hERG1/beta1 integrin complex in primary PDAC samples and PDAC cell lines."
37046674