IndraLab

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LY294002 inhibits IRF3. 4 / 4
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"LY294002, a phosphatidylinositol 3-kinase inhibitor, inhibits IRF-3 dimerization and transcriptional activity [60,61]."
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"Furthermore, our data demonstrated LY294002 inhibited IFN-β production via suppression of interferon regulatory factor 3 (IRF3) activation.C57BL/6J mice were obtained from Joint Ventures Sipper BK Exp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, we found LY294002 treatment greatly attenuated IRF3 transcriptional activation."
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"The finding that IRF3 dependent IP-10 production was inhibited by either LY294002 or wortmannin suggests that the PI3K pathway is affected by L19 involvement."
21860608