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(E)-cinnamaldehyde inhibits IRF3. 2 / 2

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"Our results showed that cinnamaldehyde suppressed the activation of NFkappaB and IRF3 induced by LPS, a TLR4 agonist, leading to the decreased expression of target genes such as COX-2 and IFNbeta in macrophages (RAW264.7)."

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"Cinnamaldehyde did not inhibit the activation of NFkappaB or IRF3 induced by MyD88 dependent (MyD88, IKKbeta) or TRIF dependent (TRIF, TBK1) downstream signaling components."

17920563

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IndraLab

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(E)-cinnamaldehyde inhibits IRF3. 2 / 2

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