IndraLab

Statements

sparser
"The study also shows that STAMBPL1 interacts with FOXO1 to promote GRHL3 transcription, which in turn activates HIF1A."
40208233
sparser
"Because the authors find that STAMBPL1 and FOXO1 interact, they suggest that STAMBPL1 may promote the formation of an active transcriptional complex containing FOXO1, perhaps by facilitating the recruitment of transcriptional coactivators."
40208233
sparser
"The results of the GST pull-down assay indicated that the N-terminus (1–140 aa) of STAMBPL1 interacted with FOXO1 ( xref )."
40208233
sparser
"Since the interaction sites of STAMBPL1-FOXO1 have been mapped, a mutant disrupting the interaction would provide better insight into how STAMBPL1 promotes GRHL3 transcription by interacting with FOXO1."
40208233
sparser
"Additionally, we found that STAMBPL1 interacts with FOXO1 to facilitate the transcription of GRHL3/HIF1α/VEGFA."
40208233
sparser
"This interaction between STAMBPL1 and FOXO1 does not necessarily affect the binding of FOXO1 with DNA, including the GRHL3 promoter."
40208233
sparser
"Additionally, an immunoprecipitation assay revealed an interaction between the FOXO1 protein (250–596 aa) and STAMBPL1 ( xref )."
40208233
sparser
"They demonstrate that STAMBPL1 interacts with FOXO1, define the required domains in each protein, and illustrate that this interaction facilitates FOXO1 transcriptional factor activity, which then activates GRHL3/HIF1a/VEGFA signaling."
40208233
sparser
"Furthermore, it would be important to determine whether the STAMBPL1-FOXO1 interaction is essential for GRHL3 transcription."
40208233