IndraLab

Statements

USP2 activates TWIST1. 3 / 3
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"In addition, USP2 activates Bmi1 and EMT by stabilizing Twist through removing ubiquitylation mediated by beta-transducin repeats containing proteins (beta-TrCP), a cellular E3 ubiquitin ligase."
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"Our work reveals that USP2 mediated Twist and Bmi1 pathway represents a cell-intrinsic mechanism crucial for CSC regulation besides EMT and provides pre-clinical evidence that targeting USP2 is indeed a promising approach for anti-CSC therapy."
30918246
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"Indeed, MG132 treatment reverted Twist downregulation mediated by USP2 depletion."
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