IndraLab

Statements

RPS6KB1 phosphorylates RPS6KB1 on T412. 11 / 11
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"In agreement with the known food dependent induction, phosphorylation of the mTORC1 target S6K1 on T389 increased after feeding (maximum of phosphorylation was observed at ZT14-ZT22) and then gradually reduced to the minimum level (at ZT6) during the rest period."
25239872
phosphoelm
No evidence text available
15388791
phosphoelm
No evidence text available
12183455
reach
"Consistent with our previous findings in HEK293 cells, incrementSin1 expression in DLD1 cells suppressed Akt Ser473 phosphorylation but had no effect on phosphorylation of the mTORC1 target p70S6K Thr389."
29156676
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"This was achieved by studying the phosphorylation of Akt residues governed by PI3K initiated events (Thr308) or by mTORC2 (Ser473) and the phosphorylation of mTORC1 targets p70S6K (Thr389) and 4E-BP1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24650799
reach
"Further, interference of p70S6K by DN-p70S6K abolished p70S6K phosphorylation at Thr 389 and resulted in increased OGG1 protein expression, confirming the role of mTOR pathway in the regulation of OGG[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20656472
biopax:phosphositeplus
No evidence text available
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"Expectedly, in normal fibroblasts, in contrast to A549 cells, AICAR induced phosphorylation of ACC at serine 79 and decreased mTOR activity, as indicated by the level of phosphorylation of the mTOR ta[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21945951
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"To evaluate the implication of glucose on E2F1-induced mTORC1 activation, cells were glucose starved or not before E2F1 induction (OHT) and mTORC1 activity was analyzed by the phosphorylation of its downstream targets p70S6 kinase (pS6K T389) and S6 (pS6 S235/236)."
31627130
reach
"Results revealed that both RPS6KB1 and its phosphorylated protein p-RPS6KB1 at T389 were highly up-regulated in NSCLC tissues, compared with controls; but only the hyperphosphorylation independently predicted the adverse prognosis of NSCLC patients."
28792981
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"Accordingly, stimulated muscle contraction increased mTORC1 signaling in skeletal muscle of control mice; phosphorylation of S6K1 Thr 389 (8-fold), S6K1 Thr 421/Ser424 (7-fold), ribosomal protein S6 (rpS6) Ser 240/244 (8-fold), rpS6 Ser 235/236 10-fold) (data not shown), and 4E-BP1 Ser 65 11-fold) were all significantly increased 2h after muscle contraction (XREF_FIG)."
25423127