IndraLab

Statements

FOXG1 increases the amount of KCNH3. 6 / 6
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"Our finding that FOXG1 increases expression of Kcnh3 extends the view that FOXG1 has important functions in mature neurons beyond integration of pyramidal neurons into the cortical plate."
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"In mature neurons, FOXG1 activates transcription of the seizure related Kcnh3, which might be a FOXG1-target gene involved in the FOXG1 syndrome pathology."
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"Our observation that FOXG1 increases Kcnh3 expression may also bear clinical relevance, as knockout mice for Kcnh3 show improved cognitive performance, enhanced spatial working memory and enhanced latent learning memory [XREF_BIBR]."
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"We concluded that Kcnh3 expression is increased by FOXG1 and FOXO3, but is independent of FOXO1 and TGFbeta signaling."
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"FOXG1 activates Kcnh3 transcription."
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"In contrast to its repressive function in Cdkn1a transcription, FOXG1 activated Kcnh3 transcription."
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