IndraLab

Statements

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"Rottlerin reduced mA3 mRNA induction by IFNalpha but not LPS in the absence of IRF3 (XREF_FIG)."
22972924
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"The inhibitory effect on LPS induced IRF3 activation by CAPE was not observed when 293T cells were reconstituted with MD2 (C133S) mutant."
23231684
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"TMED7 overexpression inhibits the ability of TRAM, an adaptor utilized by toll like receptor 4, or lipopolysaccharide to activate the interferon regulatory factor 3 signalling pathway, whereas TMED7 knockdown enhances production of the cytokine, RANTES, following lipopolysaccharide stimulation."
22426228
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"Furthermore, LPS mediated activation of IRF-3 in RAW264.7 cells was also decreased by G-Rc in our reporter assay (XREF_FIG B)."
28413316
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"LPS induced IRF3 activation is repressed in the absence of CLIC4, but enhanced when CLIC4 is overexpressed."
21469130
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"The inactive isomers of opioid receptor antagonists (+)-naltrexone and (+)-naloxonea act as TLR4 antagonists and inhibit LPS induced IRF-3 activation and subsequent IFN production."
27468646
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"To investigate the potency of TBK1 and IKKi kinase inhibition of these new compounds in living cells, we tested whether LPS induced activation of IRF3 in macrophages can be blocked by the treatment of these compounds XREF_BIBR, XREF_BIBR."
24150799
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"ILG inhibited interferon regulatory factor 3 activation induced by LPS or polyinosinic-polycytidylic acid, as well as interferon inducible genes, such as interferon inducible protein-10."
20356041
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"Additionally, to examine whether the transcription factor IRF3, which is crucial for TLR4-mediated TRIF-dependent signaling events, leading to the induction of iNOS ( Gao et al., 1998 ), is inhibited [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28465253
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"Therefore, we then determined whether saturated-strength poly(I:C) and LPS challenge triggered the degradation of endogenous IRF3."
24726876
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"Silencing MIB1 or MIB1 plus MIB2 selectively inhibited Sendai mediated IRF3 phosphorylation but had little effect on HSV- and LPS driven IRF3 activation in MEFs (XREF_FIG)."
21903422
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"As previously reported, Catalpalactone can inhibit the NO synthase (iNOS) expression and the production of NO, IL6 and tumor necrosis factor-α in the lipopolysaccharide-induced macrophage, and regulate the anti-inflammatory signaling, such as inhibiting STAT-1, IFN-β and IRF3 activation, to play a cytoprotecting role [21]."
39940010
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"Consistent with previous reports [19,30], IP-10 and IL-15 mRNA induction was dramatically decreased in LPS stimulated IRF-3 -/- DCs."
12821121
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"Interestingly, LPS, which was simply used as a control for activation of NFkB, appeared to repress IRF3 signaling in combination with 2 ' 3 '-cGAMP (XREF_FIG)."
29553248
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"We found that SA decreased LPS-induced nuclear accumulation of IRF-3, suggesting that the inhibition by SA of LPS-induced activation of IRF3 is likely to be involved in its anti-inflammatory effects."
38799138
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"In apparent contradiction to these observations, Pitha 's group reported that LPS inhibits the virus mediated activation of IRF-3 [46]."
12213596
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"In addition, LPS-induced interferon regulatory factor 3 (IRF3) activation was impaired in newborn mice [ 40 ] ( Figure 1 )."
34242953
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"Moreover, and regarding intracellular signaling, inhibition of GSK3β blocked the LPS-induced IRF3 activation in MTX-M-MØ (d5) (Fig. 6g)."
36380627
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"Inhibition of lipopolysaccharide induced interferon regulatory factor 3 activation and protection from septic shock by hydroxystilbenes."
15087825
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"On the other hand, LPS treatment down-regulated IRF3, TBK1 and TRIF in 4F treated MDMs compared to vehicle pre-treatment."
22982462
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"A recent study indicates that the palmitoylation of Lyn is required for the accumulation of this immune molecule in lipid rafts to determine the negative regulation of TLR4 induced by LPS to block the activity of the NF-κB and IRF3 signaling pathways in RAW264 cells."
39877903
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"TAG inhibited activation of IRF3 by lipopolysaccharide."
19412184
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"Our data suggest that this is associated with LPS-induced p50-NFκB signaling and impaired IRF3 activation."
30319651
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"In addition, in cells deficient for the TBK1 gene, the dsRNA-or LPS mediated activation of IRF3 and induction of IRF3 dependent genes such as interferon beta and IP-10 were considerably reduced wherea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16199137
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"As shown in Figure 3 A, LPS-induced IRF3 activation was significantly inhibited by SHP-2 overexpression in a dose-dependent manner."
17157040