IndraLab

Statements

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"Interestingly, LPS, which was simply used as a control for activation of NFkB, appeared to repress IRF3 signaling in combination with 2 ' 3 '-cGAMP (XREF_FIG)."
29553248
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"Consistent with previous reports [19,30], IP-10 and IL-15 mRNA induction was dramatically decreased in LPS stimulated IRF-3 -/- DCs."
12821121
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"ILG inhibited interferon regulatory factor 3 activation induced by LPS or polyinosinic-polycytidylic acid, as well as interferon inducible genes, such as interferon inducible protein-10."
20356041
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"In apparent contradiction to these observations, Pitha 's group reported that LPS inhibits the virus mediated activation of IRF-3 [46]."
12213596
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"To investigate the potency of TBK1 and IKKi kinase inhibition of these new compounds in living cells, we tested whether LPS induced activation of IRF3 in macrophages can be blocked by the treatment of these compounds XREF_BIBR, XREF_BIBR."
24150799
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"TAG inhibited activation of IRF3 by lipopolysaccharide."
19412184
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"Rottlerin reduced mA3 mRNA induction by IFNalpha but not LPS in the absence of IRF3 (XREF_FIG)."
22972924
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"Furthermore, LPS mediated activation of IRF-3 in RAW264.7 cells was also decreased by G-Rc in our reporter assay (XREF_FIG B)."
28413316
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"Our data suggest that this is associated with LPS-induced p50-NFκB signaling and impaired IRF3 activation."
30319651
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"Silencing MIB1 or MIB1 plus MIB2 selectively inhibited Sendai mediated IRF3 phosphorylation but had little effect on HSV- and LPS driven IRF3 activation in MEFs (XREF_FIG)."
21903422
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"In addition, in cells deficient for the TBK1 gene, the dsRNA-or LPS mediated activation of IRF3 and induction of IRF3 dependent genes such as interferon beta and IP-10 were considerably reduced wherea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16199137
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"LPS induced IRF3 activation is repressed in the absence of CLIC4, but enhanced when CLIC4 is overexpressed."
21469130
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"The inactive isomers of opioid receptor antagonists (+)-naltrexone and (+)-naloxonea act as TLR4 antagonists and inhibit LPS induced IRF-3 activation and subsequent IFN production."
27468646
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"TMED7 overexpression inhibits the ability of TRAM, an adaptor utilized by toll like receptor 4, or lipopolysaccharide to activate the interferon regulatory factor 3 signalling pathway, whereas TMED7 knockdown enhances production of the cytokine, RANTES, following lipopolysaccharide stimulation."
22426228
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"Rab11a knockdown gave a marked inhibition of E. coli - and LPS induced signaling to IRF3, whereas NF-kappaB activation was unaffected."
20933442
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"Inhibition of lipopolysaccharide induced interferon regulatory factor 3 activation and protection from septic shock by hydroxystilbenes."
15087825
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"On the other hand, LPS treatment down-regulated IRF3, TBK1 and TRIF in 4F treated MDMs compared to vehicle pre-treatment."
22982462
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"The inhibitory effect on LPS induced IRF3 activation by CAPE was not observed when 293T cells were reconstituted with MD2 (C133S) mutant."
23231684