IndraLab

Statements

ATXN3 activates CHEK1. 6 / 14
| 6
reach
"As mentioned above, ATX3 promotes Chk1 stability through inhibiting its proteasomal destruction."
28180282
reach
"Indeed, overexpression of FBXO6 or DDB1 resulted in significant decrease of Chk1 protein level, whereas co-expression of ATX3 effectively restored Chk1 from E3 ligase mediated degradation."
28180282
reach
"Ataxin-3 promotes genome integrity by stabilizing Chk1."
28180282
reach
"Moreover, ATX3 depleted cells re-entered the cell cycle more rapidly than WT cells did, implying that Chk1 reduction caused by ATX3 knockout can accelerate recovery from the G2/M damage checkpoint, which is consistent with previous results from Chk1-/- ES cells."
28180282
reach
"To test if ATX3 may promote Chk1 stabilization, we first evaluated whether ATX3 deficiency impairs Chk1 stability."
28180282
reach
"Taken together, our results demonstrated that ATX3 promoted Chk1 stability through the ubiquitin-proteasome pathway."
28180282