IndraLab

Statements

USP7 increases the amount of NLRP3. 4 / 4
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reach
"Our results demonstrated that E2-activtated mTORC1 promoted USP7 stability, which promoted OS cell proliferation and migration via upregulating NLRP3 expression and enhancing NLRP3 inflammasome signaling pathway."
38467635
reach
"USP7 deubiquitinated NLRP3 through K48-ubiquitination to increase the NLRP3 expression and the ASC speck formation."
38467635
reach
"Our results demonstrated that E2-activtated mTORC1 promoted USP7 stability, which promoted OS cell proliferation and migration via upregulating NLRP3 expression and NLRP3 inflammasome signaling pathway."
38467635
reach
"The overexpression of USP7 enhanced pyroptosis, ROS production, interleukin (IL)-1beta and IL-18 levels, and the expression level of NLRP3, GSDMD-N, active caspase-1, pro-caspase-1, matrix metalloproteinases (MMP) 1, and MMP13, which was abolished by ROS inhibition."
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