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USP18 inhibits GSDME. 2 / 2

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"USP18 suppression could induce cancer cell GSDME-dependent pyroptosis and suppress leukemogenesis via upregulating PLK2, an atypical ISG [24] (Fig. 2A)."

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"USP18 depletion induces both GSDMD and GSDME-dependent pyroptosis upon IFN treatment."

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USP18 inhibits GSDME. 2 / 2

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