IndraLab

Statements


USP25 activates CXCL8. 5 / 5
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"On the other hand, USP21 also mediates transcriptional initiation of IL8 leading to an expansion of the stem cell pool in renal carcinoma cells 13."

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"Our results showed that knockdown of USP21 led to decrease of IL-8 secretion in RCC cell lines."

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"In addition, it was demonstrated that USP21 directly targets IL-8 in RCC cells."

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"Our study demonstrates that IL-8 affects the CSCs activity in RCC and how IL-8 activity is mediated by USP21 through its binding to the promoter region."

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"USP21 also mediates transcriptional initiation of IL-8 by binding to its promoter 13."