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USP28 activates KDM1A. 6 / 6
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"These findings highlight the critical role of USP28-mediated LSD1 stabilization in maintaining CSC-like properties and driving tumorigenicity.In glioblastoma, the deubiquitinase USP22 facilitates LSD1 stabilization in a glycogen synthase kinase 3β (GSK3β)-dependent manner ."
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"Overexpression of HDAC5 significantly increases USP28 expression in cell lines and reduces USP28 polyubiquitination, supporting the idea that HDAC5 stabilizes LSD1 by enhancing its deubiquitinase prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"First, our data indicates that USP28 is a specific DUB for LSD1, as knockdown of USP28 reduced LSD1 stability, whereas overexpression of USP28 stabilized LSD1."
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"Interestingly, the downregulation of LSD1 by two independent USP28 shRNAs in HCT116 cells could be restored by MG132 treatment (XREF_FIG), indicating that USP28 enhances LSD1 stabilization through a deubiquitination event."
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"In agreement with this notion, knockdown of USP28 reduced the protein level and functional activity of LSD1, but these could be rescued by exogenous LSD1 expression (XREF_FIG)."
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"To test whether USP28 directly regulates protein stability of LSD1, we co-expressed LSD1 with USP28 or vector control in HEK293 cells and examined the degradation of LSD1."
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