IndraLab

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USP9X deubiquitinates NRP1. 4 / 4
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"We found that USP9X was a critical deubiquitinating enzyme which primarily responsible for the NRP1 stability and NRP1 deubiquitination mediated by USP9X enhanced HSC activation."
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"Given the preceding findings, we postulate that USP9X performs its function by deubiquitinating NRP1."
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"Moreover, USP9X was found to be a critical deubiquitinating enzyme for the stability and high activity of NRP1 and NRP1 deubiquitination mediated by USP9X enhanced HSC activation and liver fibrosis."
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"NRP1 deubiquitination mediated by USP9X enhances HSC activation, implying that targeting NRP1 or USP9X potentiates novel options in the treatment of liver fibrosis."
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