IndraLab

Statements

Sulforaphane inhibits CASP1. 9 / 9
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"[29] SFN also reduces cleavage of caspase-1 and caspase-3,[1230313233] increases the production of the anti-inflammatory cytokines IL-4 and IL-10,[2534] and reduces the amount of gliosis, apoptosis, and necrosis in response to toxins."
31334360
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"Sulforaphane might inhibit NLRP3 inflammasome activation by affecting ASC or caspase-1 [80]."
40155968
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"SFN inhibited palmitate induced production of caspase-1 (p10) and mature IL-1beta in hepatocyte cell supernatant (XREF_FIG)."
27075683
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"Mechanistically, SFN reduced messenger ribonucleic acid and protein levels of TLR4, NLRP3, apoptosis-associated speck-like protein, and Caspase-1 in C2C12 cells, thereby inhibiting the inflammatory response and promoting myogenic differentiation."
36398371
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"Earlier reports have suggested that SFN inhibited caspase-1 cleavage and IL-1beta maturation for the NLRP1b, NLRP3, NAIP5 and NLRC4, and AIM2 inflammasomes in immune cells [XREF_BIBR]."
27847555
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"When SFN was added directly to the cell lysates, it did not inhibit IL-1beta processing, demonstrating that SFN does not directly inhibit the protease activity of caspase-1."
27672241
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"Greaney et al. (2016) also showed that the SFN inhibits caspase-1 autoproteolytic cleavage but does not modify cysteine residues in the caspase-1 active site, as incubation with SFN in the presence of active caspase-1 does not inhibit the IL-1β processing."
35754962
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"Oral administration of SFN inhibited HFD induced upregulation of ASC and caspase-1 in the liver (XREF_FIG)."
27075683
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"Findings of the present study indicate that sulforaphane and WE reduced caspase-1 activation."
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