IndraLab

Statements

Sulforaphane inhibits CASP1. 6 / 6
| 6
reach
"Mechanistically, SFN reduced messenger ribonucleic acid and protein levels of TLR4, NLRP3, apoptosis-associated speck-like protein, and Caspase-1 in C2C12 cells, thereby inhibiting the inflammatory response and promoting myogenic differentiation."
36398371
reach
"Earlier reports have suggested that SFN inhibited caspase-1 cleavage and IL-1beta maturation for the NLRP1b, NLRP3, NAIP5 and NLRC4, and AIM2 inflammasomes in immune cells [XREF_BIBR]."
27847555
reach
"Oral administration of SFN inhibited HFD induced upregulation of ASC and caspase-1 in the liver (XREF_FIG)."
27075683
reach
"SFN also prevented caspase-1 dependent pyroptotic cell death in microglia."
33711331
reach
"When SFN was added directly to the cell lysates, it did not inhibit IL-1beta processing, demonstrating that SFN does not directly inhibit the protease activity of caspase-1."
27672241
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"SFN inhibited palmitate induced production of caspase-1 (p10) and mature IL-1beta in hepatocyte cell supernatant (XREF_FIG)."
27075683