The INDRA Database

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"USP8 inhibition via genetic and pharmacological approaches resulted in growth inhibition and apoptosis induction in both sensitive and doxorubicin resistant HCC cells."

34081623

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"More interestingly, knockdown of USP8 was reported to induce apoptosis of HER3-positive GC cells and reduce the cell growth or viability by arresting the cell cycle [ 56 ]."

33600786

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"This study also shows that USP8 overexpression promotes PCa cell growth, survival, and migration and suppresses apoptosis."

36338727

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"Our work showed that USP8 silencing promoted ESCC cell apoptosis and inhibited cell invasion, migration, stem‐like cell properties, and glucose metabolism."

39702934

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"USP8 prevents extrinsic apoptosis, initiated by the ligation of anti-FAS antibody, TNF, or TNFSF10 to their specific receptors, through the direct deubiquitylation and stabilization of CFLAR rather than regulating the expression or surface availability of death receptors in cervical cancer and melanoma cells [16]."

36551253

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"High expression of USP8 can therefore inhibit extrinsic apoptosis by stabilizing FLIP L [XREF_BIBR]."

30010158

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"Our results are also consistent with the finding that USP8 inhibits extrinsic apoptosis because when using the most efficient siRNA i.e., siRNA b to inhibit USP8, cisplatin-induced caspase 8 activation was evident.Molecular targeting of USP8 was also carried out in the IGROV-1 parental cell line and in the PEO1 cells."

36578788

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eidos

"In the present study , our objective is to study in broad the secondary down-stream effect after depleting USP5 or USP8 , which were initially showed to induce apoptosis in various cancers ."

33319070

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"Knockdown of USP8 inhibited the proliferation, migration, invasion, and cell cycle progression of A549 and H1299 cells, and promoted the apoptosis."

33293867

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"Such a difference was not evident in IGROV-1 and IGROV-1/Pt1 cells, likely depending on the different molecular background.Overall, the mechanism by which USP8 reduces cisplatin activity is linked to a change in tumor cell susceptibility to apoptosis."

36578788

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"Depletion of USP8 destabilized cFLIP resulting in sensitization to DR-induced apoptosis."

31845722

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"USP8 DUB prevents c-FLIP L, degradation and further halts the apoptosis in cancer cells suggesting it to be a potential drug target."

29479529

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"Consistently, knockdown of USP8 significantly increased apoptosis of PIK3CA mutant cells even in the presence of glutamine (XREF_SUPPLEMENTARY)."

27321283

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"Depletion of USP8 destabilized c-FLIP(L) through ubiquitin-proteasome pathway leading to sensitization of TRAIL-induced apoptosis in vitro and in a xenograft model (76)."

30638181

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"The silencing USP8 and docetaxel treatment reduced cell viability and migration and promoted apoptosis."

36338727

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"USP8 inhibitor , DUB-IN-1 , treatment could inhibit esophageal squamous cell carcinoma cell growth and induce G2 / M cell cycle arrest , apoptosis , and autophagy by DNA damage-induced p53 activation ."

35022897

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"In accord, USP8 limits TNF-, CD95L-, and TRAIL-induced apoptosis, the latter also in vivo [89] ."

29195774

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"USP8 knockdown markedly induced apoptosis and cell cycle arrest ( G 0 / G 1 ) ."

36644233

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"DUB-IN-1 , an USP8 inhibitor , caused DNA damage , led to G2 / M phase block by p53-p21 axis , and triggered apoptosis by regulating the p53 target proteins including Bax , Noxa , and Puma ."

35022897

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"Knockdown of USP8 Promotes the Apoptosis of Lung Cancer Cells."

33293867

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"After transfection with siRNA1 or siRNA2, the expression of Bcl2 was reduced, while the expression of Bax was increased significantly both in A549 and H1299 cells (Figure 4B), indicating that knockdown of USP8 can induce apoptosis of lung cancer cells."

33293867

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"These results demonstrated that knockdown of USP8 promoted cell apoptosis of lung cancer cells by regulating the PI3K/AKT pathway."

33293867

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"The data showed that knockdown of USP8 inhibited the proliferation and promoted the apoptosis of lung cancer cells."

33293867

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"Suppression of USP8 in ARID1A-deficient OCCC cells induces apoptosis."

40074856

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"High expression of USP8 can therefore inhibit extrinsic apoptosis by stabilizing FLIP L [ xref ] ."

30010158

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"Silencing of USP8 reduced viability, EdU‐positive cell rate, invasive cell number, and enhanced apoptosis rate in A549 and H1299 cells, while these effects were abolished by PTK7 overexpression (Figure 4b–g and Figure S1)."

39552193

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"In Fig. 3, we showed that USP8 inhibition induces apoptosis in ARID1A-deficient cells; this was supported by GSEA, which indicated that genes differentially expressed upon USP8 suppression in ARID1A-deficient cells were indeed associated with the HALLMARK_APOPTOSIS pathway (Fig. 5E–G, Supplementary Fig. 5G, H)."

40074856

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"Compared to the vector + sh-NC group, the expression of Bax, cleaved caspase-3, and cleaved PARP proteins increased in the SCNN1A silencing group, and the protein expression of Bcl-2 was inhibited, wh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

37741774

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"USP8 knockdown markedly induced apoptosis and cell cycle arrest (G0/G1)."

36644233

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"Taken together, our data indicate that USP8 functions as a novel deubiquitylase of FLIP L and inhibits extrinsic apoptosis by stabilizing FLIP L."

27321185

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"USP8 can directly remove ubiquitination and inhibit exogenous apoptosis by stabilizing FLIPL, a death receptor that regulates apoptosis [18] ."