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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP9X decreases the amount of YAP1. 3 / 3

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"Depletion of USP9X in ovarian cancer cell line OVCAR8 also downregulated YAP1 protein levels (XREF_SUPPLEMENTARY)."

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"Similarly, depletion of USP9X in cells using two specific shRNAs significantly decreased YAP1 protein levels (XREF_FIG) and increased cellular sensitivity to MMC, cisplatin and etoposide (XREF_FIG), while reconstituting USP9X depleted cells with FLAG-YAP1 reversed chemotherapy drugs hypersensitivity (XREF_FIG)."

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"Concersely, depletion of USP9X in MDA-MB-231 cells significantly decreased YAP1 protein level but did not affect YAP1 mRNA level (XREF_FIG)."

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USP9X decreases the amount of YAP1. 3 / 3

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