IndraLab

Statements

USP27X activates CBX2. 5 / 5
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"USP27X enhances CBX2 protein stability."
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"Similarly, MG132 counteracted the upregulation of CBX2 caused by USP27X overexpression (Fig. 2G, H)."
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"USP27X promotes the proliferation, invasion, and metastasis of BC cells by up-regulating CBX2."
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"As anticipated, the capacity of USP27X mimetic phosphorylation-inactivated phenotype (USP27X S135A) to sustain CBX2 stability was significantly diminished compared to that of USP27X, while the ability of USP27X mimetic phosphorylation-activated phenotype (USP27X S135Q) to maintain CBX2 stability was considerably augmented (Fig. 5L, M)."
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"We have demonstrated that the overexpression of USP27X results in an increase in CBX2 levels through deubiquitination, while the deficiency of USP27X promotes CBX2 degradation and restrains tumorigenesis."
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