IndraLab

Statements

TNF decreases the amount of CD4. 7 / 8
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"TNF-alpha and IL-1 beta, proinflammatory cytokines which are both induced by LPS, also down-regulate surface and total CD4 expression in TCDM."
7586702
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"This down-regulation of CD4 expression by LPS, TNF-alpha, and IL-1 beta occurs at the level of transcription."
7586702
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"Actually, TNFalpha down-regulates both surface and total CD4 expression in primary human macrophages at the transcription level [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
20380698
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"TNFalpha, IL-1beta and IFN-gamma down-regulate both surface and total CD4 expression in primary human macrophages at the level of transcription [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
20380696
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"Our study revealed that the EAM induced group showed increased proinflammatory cytokines and reduced levels of anti-inflammatory cytokines with enhanced expression of positive T cells (CD4, CD8, CD45 and CD11β), while treatment with Boswellia gum extract was able to increase IL-10 and IL-4 levels, reduce TNF-α, IL-6, IL-2, and IL-17, and to suppress the expression of CD4, CD8, CD45, and CD11β."
36358503
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"Our results show that LPS, TNF-alpha and IL-1 beta selectively down-regulate CD4 expression in primary human macrophages, and that decreased CD4 expression induced by LPS results from endogenous secretion of TNF-alpha and IL-1 beta by the macrophages."
7586702
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"Although prolonged (1 to 5 days) TNFalpha treatment can downregulate CD4 expression in primary human TCDM, surface CD4 levels were not reduced by 2 h of treatment and was therefore not a limiting step for HIV-1 entry."
8892857