IndraLab

Statements

CYLD inhibits TNF. 8 / 14
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"First, individually KO of CYLD, caspase-8, and FADD (required for caspase-8 activation) in HeLa cells (Fig. 3 A) and KO of CYLD and caspase-8 in HCT-116 cells (Fig. 3 B) blocked TNF/IFNγ-induced cell death."
38319288
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"OPTN is required for CYLD dependent deubiquitination of RIP and also for CYLD dependent inhibition of TNFalpha induced by NF-kappaB activity."
29951055
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"CYLD can limit TNF induced prosurvival signaling and promote cell death [XREF_BIBR - XREF_BIBR]."
33432113
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"CYLD suppresses NF-κB activation induced by TLRs, T and B-cell antigen receptors, and the TNF-α receptor [14]."
39158695
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"Concomitant Loss of OTULIN and CYLD Interaction with HOIP Increases M1Ubiquitination at the TNF-RSC and Enhances TNF Induced Gene Activation."
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"CYLD antagonizes the TNF-α signaling and is involved in cell death [24] ."
28189684
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"In contrast, the loss of CYLD led to significant TRAF6 activation, and promoted TNF-α and IL-6 production."
40108019
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"The tumor suppressor cylindromatosis (CYLD) inhibits the NF-kappaB pathway by deubiquinating the IKKgamma subunit, as well as TNF receptor associated factor (TRAF) 2, TRAF6, and B-Cell CLL and Lymphoma 3 (BCL3) that are required for maintaining NF-kB activity."
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