IndraLab

Statements

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"In previous experiments, we found that targeting USP28 with AZ1 induces DNA damage in non-small cell lung cancer while also inhibiting DNA repair."
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"Further, the high expression of the deubiquitinating enzyme USP28 was targeted by miR-4295, promoting non-small cell lung cancer cell proliferation [45]."
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"As a target gene of miR-4295, the high expression of USP28 will promote the occurrence of non-small cell lung cancer,14 promote the proliferation, metastasis, and angiogenesis of cancer cells, and inhibit the apoptosis of cancer cells.34 To sum up, the low expression of miR-4295 will weaken the targeted inhibitory effect on USP28, thus showing a cancer-promoting effect."
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