IndraLab

Statements

CTSG binds KCNH2. 5 / 5
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"This may explain why the cg form of hERG is decreased during hypoxia but results in ER retention in the case of mutants."
19654002
sparser
"Exposure of cells to hypoxia at lower temperatures (30°C and 23°C), fully restored the expression of the cg form of hERG to normoxic levels ( xref )."
19654002
sparser
"Taken together these results suggest that hypoxia inhibits maturation of the hERG cg form to the fg form, which does not result in an increased degradation rate nor in accumulation of the ER form."
19654002
sparser
"More importantly, addition of MnTMPyP during hypoxia restored Hsp90 interaction with cg form of hERG (lane 3 vs lane 4, xref )."
19654002
sparser
"Considering that 60% of the cg form of wild type hERG is processed to the fg form and the remaining 40% cg form is degraded by the ubiquitin proteasome pathway [17] , we examined whether the decrease[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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