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USP37 binds E3_Ub_ligase. 2 / 2

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"Early work showed that USP37 binds the APC/C CDH1 E3 complex to regulate ubiquitylation of cyclin A, a substrate of APC/C CDH1 [ 28 ]."

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"Mutations in UIM2 and UIM3 abrogate binding to K48- and K63-linked Ub 4 chains, similar to published work [ 16 ], but also to K11-linked Ub 4 chains, which are produced by APC CDH1 , the E3 ligase a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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IndraLab

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USP37 binds E3_Ub_ligase. 2 / 2

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