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ATP activates KCNMA1. 10 / 10
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"Inclusion of SLO in T cell culture diminished PIP3 generation, whereas ATP supplementation together with SLO enhanced PIP3 production in both Ldha and Cd4 Ldha T cells (Figures 7A and S7A)."
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"The most prominent current componentduring ATP stimulation in hslo expressing cells was conducted BK,, which resulted in a pronouncedtransient hyperpolarization.This hyperpolarization, which was absen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In conclusion, our results indicate that PACAP causes cerebellar artery dilation through two mechanisms : 1) K ATP channel activation and 2) enhanced BK channel activity, likely through increased Ca 2+ spark frequency."
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"Thus, at positive membrane potential, the activation of the BK channel caused by ATP was sufficient to counterbalance the inhibition of the BK channel caused by the chelation of free calcium by ATP; at negative membrane potential, however, the effect of ATP on P open was more inhibitory than would be expected, even bearing in mind the chelation of free calcium by ATP."
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"BK channel open probability (Po) of all cells lines used was increased by H 2 S in ATP containing solutions."
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"In the vasculature, the most important K+ channel subclasses that are involved in the action of various endothelium derived relaxing factors are the ATP sensitive KATP channel and the large conductance calcium activated BK channel."
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"The most prominent current component during ATP stimulation in hslo expressing cells was conducted BK (Ca) which resulted in a pronounced transient hyperpolarization."
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"A number of ATP-activated K and Ca -activated K (BK or maxi-K and SK) channel openers have demonstrated that activation of potassium channels can reduce the spontaneous or stimulus-induced contractions of isolated bladder strips [110]."
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"SLO alone inhibited Akt and Foxo1 phosphorylation; by contrast ATP supplementation together with SLO enhanced Akt-Foxo1 signaling and corrected the defects associated with LDHA deficiency (Fig. 3C and fig."
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"In cell attached recordings, ATP activated a 230-pS BK channel."
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