IndraLab

Statements

Neoplasms activates USP22. 5 / 5
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"In tumors overexpressing USP22, specific inhibitors such as those already developed for USP7 and USP8 are imaginable [88] ."
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"Furthermore, our study indicated that SOS1 was upregulated in USP22-overexpressing gastric cancer cells and xenograft tumor tissue, accompanied by activation of the RAS/ERK and PI3K/AKT pathways, suggesting that SOS1/RAS signaling mediates the oncogenic role of USP22 in gastric cancer."
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"Tumor-derived TGF-beta selectively induces Usp22 and Usp21 in T reg cells."
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"IHC staining showed that the tumors developed from USP22-overexpressing SGC7901 cells had significantly increased USP22 and Ki-67 staining and decreased TUNEL staining, compared with the control group (Fig. 4d)."
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"Two weeks later, when the tumor size was approximately 100 mm , mice carrying USP22-overexpressing tumors were randomly divided into two groups (n = 4): siRNA of ZEB1 (7.5 μg) was injected into the tumor, and the other group was injected with the same amount of negative control every 72 h for another 2 weeks."
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