IndraLab

Statements

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"The aim of this study was to investigate whether DHA can more efficiently inhibit protein degradation than EPA by regulating IkappaBalpha and NFkappaB pathway in C2C12 myotubes in a PPARgamma dependent manner."
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"We discovered that DHA directly inhibits IkappaBalpha kinase beta (IKKbeta) and IKKalpha enzymatic activity in vitro, whereas AA did not have this effect."
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"Stimulation with EPA or AA, but not DHA, inhibited IL-1beta induced breakdown of IkappaBalpha significantly (p < 0.05) compared to treatment with IL-1beta alone."
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"Taken together, these results revealed that DHA, more efficiently than EPA, inhibited the protein degradation by regulating IkappaBalpha and NFkappaB signaling pathway in C2C12 myotubes by activating PPARgamma gene expression."
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