IndraLab

Statements

PMAIP1 inhibits USP9X. 2 / 3
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reach
"These results suggest that BIX-01294 degrades the MCL1 through up-regulation of PMAIP1 and reduction of USP9X, which is consistent to our previous study that PMAIP1 upregulation reduces the availability of USP9X to MCL1, thereby promoting its ubiquitination and degradation, leading to the apoptosis of neoplastic cells [XREF_BIBR]."
25685062
reach
"In conclusion, after pemetrexed treatment in NSCLC cells, Noxa downregulated Usp9x, resulting in a decrease in Mcl-1 and eventually leading to apoptosis."
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