IndraLab

Statements

PMAIP1 inhibits USP9X. 4 / 5
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reach
"This is supported by the observation that siRNA-mediated knockdown of NOXA promotes USP9x availability to Mcl-1, leading to a lower rate of apoptosis."
37584295
reach
"These results suggest that BIX-01294 degrades the MCL1 through up-regulation of PMAIP1 and reduction of USP9X, which is consistent to our previous study that PMAIP1 upregulation reduces the availability of USP9X to MCL1, thereby promoting its ubiquitination and degradation, leading to the apoptosis of neoplastic cells [XREF_BIBR]."
25685062
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"In conclusion, after pemetrexed treatment in NSCLC cells, Noxa downregulated Usp9x, resulting in a decrease in Mcl-1 and eventually leading to apoptosis."
24991768
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"Moreover, high levels of PMAIP1 have been demonstrated to reduce the binding of ubiquitin-specific protease 9X (USP9X) to MCL1, thereby promoting the ubiquitination and degradation of MCL1, leading to apoptosis in cancer cells (Cui et al., 2015)."
38547674