IndraLab

Statements

USP22 activates FOXP3. 5 / 5
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"Recent studies demonstrate that USP22 is a promising target for cancer immunotherapy, since USP22 positively regulates FOXP3 activity in mouse Treg cells that suppress antitumor immune responses, and Treg-specific USP22-knockout (USP22-Ko) suppressed in vivo Treg function to improve antitumor immunity [31]."
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"USP22 positively regulated transcription factor FOXP3 activity in mouse regulatory T (T reg) cells."
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"Our findings that hypoxia induced Usp22 in a HIF-dependent manner, and loss of Usp22 resulted in diminished Foxp3 stability, imply that hypoxia can stabilize T cells through Usp22-mediated Foxp3 stabilization."
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"USP22 positively regulated transcription factor FOXP3 activity in mouse regulatory T (T reg) cells."
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"T cells from the dKO mice displayed a GSEA and bulk gene expression signature that merged the changes found in each of the single KO mice, suggesting that the loss of both Usp22 and Usp21 synergizes to diminish T cell function (Fig. 4G) in both Foxp3-depedent and Foxp3-independent manner.As we demonstrated that both Usp22 and Usp21 are regulated by metabolic alterations in the TME, it was particularly interesting to identify disruption of multiple metabolic pathways in each of the KO groups."
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