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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

MTORC2 activates KCNMA1. 4 / 4

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"These data indicate mTORC2 mediated BK channel activity by influencing the surface expression of BK channels through Akt."

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"Inhibition of mTORC2 Decreases BK Channel mRNA and Protein Levels in Podocytes."

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"In summary, our study demonstrated that inhibition of mTORC2 downregulates BK channel mRNA and protein levels and functions in podocytes."

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"However, the dual inhibitor of mTORC1 and mTORC2 AZD8055 and short hairpin RNA targeting Rictor downregulated BK channel mRNA and protein levels and bioactivity."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

MTORC2 activates KCNMA1. 4 / 4

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