IndraLab

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USP47 activates SNAI1. 6 / 6
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"Interestingly, treatment with a pharmacological inhibitor targeting USP47 (P5091) upregulated E-cadherin and downregulated SNAIL both in the nucleus and cytoplasm, while reducing morphological changes otherwise observed in MCF10A cells treated with TGF-β2 [78]."
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"Additionally, chemical inhibition of USP47 reduced the expressions of several EMT markers, including CDH1, CTNNB1, and SNAIL, and reversed the morphological changes in MCF-10A cells undergoing EMT (Silvestrini et al., 2020)."
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"Silencing of USP47 accelerated the proteasomal degradation of Snail and inhibited EMT."
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"Additionally, in the presence of protein translation inhibitor cycloheximide (CHX), the degradation of USP47 markedly accelerated the protein turnover of Snai1 in HGC-27 cells (Supplemental Figure 12F)."
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"Because hypoxia induced USP47 expression enhanced EMT by stabilizing Snail, we investigated the contribution of USP47 to tumor growth and invasion in vivo."
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"Consistently, the depletion of USP47 by shRNAs enhanced Snai1 turnover in both HGC-27 and GT38 cells (Supplemental Figure 12G)."
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