IndraLab

Statements

USP18 decreases the amount of ISG15. 5 / 5
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"We demonstrated that USP18 deficient cells have increased expression of IFIT1, IFIT2, IFIT3, IFITM1, IFITM2, CXCL9, CXCL10, ISG15, and MX2 after treatment with exogenous IFN‐β."
29437254
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"As USP18 deconjugates ISGylation and promotes ISG15 secretion, loss of USP18 increases the intracellular level of ISG15."
36736853
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"Knockout of USP18 promotes a higher level of ISG15/ISGylation of p53 and c-myc, which led to higher rate of spontaneous leiomyosarcomas [ 69 ]."
36736853
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"Here, we provide an acute example of this phenomenon, whereby the early expression of USP18, post-interferon treatment of HCT116 colon cancer cells is sufficient to fully suppress the expression of the ISG15 E1 enzyme, UBA7."
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"As expected, incubation with purified USP18 decreased ISG15 conjugates and increased levels of free ISG15 [88]."
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